The simplest version of the model has 684 states per region. (2020) fit an age structured SEIR model with added health service compartments to data on deaths, hospitalization and test results from Covid-19 in seven English regions for the period March to December 2020. In a major study of the Covid-19 epidemic in England, Knock et al. The inclusion of mechanistic detail in models of highly complex systems has the potential to increase realism, but it also increases the number of modelling assumptions, which become harder to check as their possible interactions multiply. Detail is a double edged sword in epidemiological modelling.
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